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Cytokine Network Involvement in Subjects Exposed to Benzene
Joint Authors
Navarra, Michele
Minciullo, Paola Lucia
Gangemi, Sebastiano
Calapai, Gioacchino
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Benzene represents an ubiquitous pollutant both in the workplace and in the general environment.
Health risk and stress posed by benzene have long been a concern because of the carcinogenic effects of the compound which was classified as a Group 1 carcinogen to humans and animals.
There is a close correlation between leukemia, especially acute myeloid leukemia, and benzene exposure.
In addition, exposure to benzene can cause harmful effects on immunological, neurological, and reproductive systems.
Benzene can directly damage hematopoietic progenitor cells, which in turn could lead to apoptosis or may decrease responsiveness to cytokines and cellular adhesion molecules.
Alternatively, benzene toxicity to stromal cells or mature blood cells could disrupt the regulation of hematopoiesis, including hematopoietic commitment, maturation, or mobilization, through the network of cytokines, chemokines, and adhesion molecules.
Today there is mounting evidence that benzene may alter the gene expression, production, or processing of several cytokines in vitro and in vivo.
The purpose of this review was to systematically analyze the published cases of cytokine effects on human benzene exposure, particularly hematotoxicity, and atopy, and on lungs.
American Psychological Association (APA)
Minciullo, Paola Lucia& Navarra, Michele& Calapai, Gioacchino& Gangemi, Sebastiano. 2014. Cytokine Network Involvement in Subjects Exposed to Benzene. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1041014
Modern Language Association (MLA)
Minciullo, Paola Lucia…[et al.]. Cytokine Network Involvement in Subjects Exposed to Benzene. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1041014
American Medical Association (AMA)
Minciullo, Paola Lucia& Navarra, Michele& Calapai, Gioacchino& Gangemi, Sebastiano. Cytokine Network Involvement in Subjects Exposed to Benzene. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1041014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041014