The Expression of Bcl-2 and BID in Gastric Cancer Cells
Joint Authors
Zareba, Konrad
Pryczynicz, Anna
Kemona, Andrzej
Guzińska-Ustymowicz, Katarzyna
Kedra, Boguslaw
Gryko, Mariusz
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis.
The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients’ survival.
Materials and Methods.
The study involved 88 patients operated on for gastric cancer.
The expressions of Bcl-2 and BID were determined immunohistochemically.
Results.
Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients.
The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer P < 0.05 , with the intestinal type according to Lauren P < 0.001 , ulcerated type according to Bormann’s classification P < 0.01 , and with local lymph node metastases P < 0.05 .
Conclusion.
The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.
American Psychological Association (APA)
Gryko, Mariusz& Pryczynicz, Anna& Zareba, Konrad& Kedra, Boguslaw& Kemona, Andrzej& Guzińska-Ustymowicz, Katarzyna. 2014. The Expression of Bcl-2 and BID in Gastric Cancer Cells. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1041019
Modern Language Association (MLA)
Gryko, Mariusz…[et al.]. The Expression of Bcl-2 and BID in Gastric Cancer Cells. Journal of Immunology Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1041019
American Medical Association (AMA)
Gryko, Mariusz& Pryczynicz, Anna& Zareba, Konrad& Kedra, Boguslaw& Kemona, Andrzej& Guzińska-Ustymowicz, Katarzyna. The Expression of Bcl-2 and BID in Gastric Cancer Cells. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1041019
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041019