![](/images/graphics-bg.png)
The Relevance of HLA Sequencing in Population Genetics Studies
Joint Authors
Sanchez-Mazas, Alicia
Meyer, Diogo
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Next generation sequencing (NGS) is currently being adapted by different biotechnological platforms to the standard typing method for HLA polymorphism, the huge diversity of which makes this initiative particularly challenging.
Boosting the molecular characterization of the HLA genes through efficient, rapid, and low-cost technologies is expected to amplify the success of tissue transplantation by enabling us to find donor-recipient matching for rare phenotypes.
But the application of NGS technologies to the molecular mapping of the MHC region also anticipates essential changes in population genetic studies.
Huge amounts of HLA sequence data will be available in the next years for different populations, with the potential to change our understanding of HLA variation in humans.
In this review, we first explain how HLA sequencing allows a better assessment of the HLA diversity in human populations, taking also into account the methodological difficulties it introduces at the statistical level; secondly, we show how analyzing HLA sequence variation may improve our comprehension of population genetic relationships by facilitating the identification of demographic events that marked human evolution; finally, we discuss the interest of both HLA and genome-wide sequencing and genotyping in detecting functionally significant SNPs in the MHC region, the latter having also contributed to the makeup of the HLA molecular diversity observed today.
American Psychological Association (APA)
Sanchez-Mazas, Alicia& Meyer, Diogo. 2014. The Relevance of HLA Sequencing in Population Genetics Studies. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1041042
Modern Language Association (MLA)
Sanchez-Mazas, Alicia& Meyer, Diogo. The Relevance of HLA Sequencing in Population Genetics Studies. Journal of Immunology Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1041042
American Medical Association (AMA)
Sanchez-Mazas, Alicia& Meyer, Diogo. The Relevance of HLA Sequencing in Population Genetics Studies. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1041042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041042