microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
Joint Authors
Ge, Qian
Brichard, Sonia
Yi, Xu
Li, Qifu
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obesity is associated closely with the metabolic syndrome (MS).
It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS.
White adipose tissue (AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation.
Exploring the mechanisms of white AT inflammation and resetting the immunological balance in white AT could be crucial for the management of MS.
Several prominent molecular mechanisms have been proposed to mediate inflammation in white AT, including hypoxia, endoplasmic reticulum stress, lipotoxicity, and metabolic endotoxemia.
Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity.
This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.
American Psychological Association (APA)
Ge, Qian& Brichard, Sonia& Yi, Xu& Li, Qifu. 2014. microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1041044
Modern Language Association (MLA)
Ge, Qian…[et al.]. microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome. Journal of Immunology Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1041044
American Medical Association (AMA)
Ge, Qian& Brichard, Sonia& Yi, Xu& Li, Qifu. microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1041044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041044