Serum PCSK9 Levels Distinguish Individuals Who Do Not Respond to High-Dose Statin Therapy with the Expected Reduction in LDL-C
Joint Authors
Pescatello, Linda S.
Panza, Gregory
Chipkin, Stuart
Gipe, Daniel
Shao, Weiping
White, C. Michael
Thompson, Paul D.
Parker, Beth A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
The purpose of the present report was to examine whether proprotein convertase subtilisin/kexin type 9 (PCSK9) levels differ in individuals who do not exhibit expected reductions in low density lipoprotein cholesterol (LDL-C) with statin therapy.
Eighteen nonresponder subjects treated with 80 mg atorvastatin treatment for 6 months without substantial reductions in LDL-C (ΔLDL-C: 2.6 ± 11.4%) were compared to age- and gender-matched atorvastatin responders (ΔLDL-C: 50.7 ± 8.5%) and placebo-treated subjects (ΔLDL-C: 9.9 ± 21.5%).
Free PCSK9 was marginally higher in nonresponders at baseline (P=0.07) and significantly higher in atorvastatin responders after 6 months of treatment (P=0.04).
The change in free PCSK9 over 6 months with statin treatment was higher (P<0.01) in atorvastatin responders (134.2 ± 131.5 ng/mL post- versus prestudy) than in either the nonresponders (39.9 ± 87.8 ng/mL) or placebo subjects (27.8 ± 97.6 ng/mL).
Drug compliance was not lower in the nonresponders as assessed by pill counts and poststudy plasma atorvastatin levels.
Serum PCSK9 levels, both at baseline and in response to statin therapy, may differentiate individuals who do versus those who do not respond to statin treatment.
American Psychological Association (APA)
Parker, Beth A.& Panza, Gregory& Pescatello, Linda S.& Chipkin, Stuart& Gipe, Daniel& Shao, Weiping…[et al.]. 2014. Serum PCSK9 Levels Distinguish Individuals Who Do Not Respond to High-Dose Statin Therapy with the Expected Reduction in LDL-C. Journal of Lipids،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-1041047
Modern Language Association (MLA)
Parker, Beth A.…[et al.]. Serum PCSK9 Levels Distinguish Individuals Who Do Not Respond to High-Dose Statin Therapy with the Expected Reduction in LDL-C. Journal of Lipids No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-1041047
American Medical Association (AMA)
Parker, Beth A.& Panza, Gregory& Pescatello, Linda S.& Chipkin, Stuart& Gipe, Daniel& Shao, Weiping…[et al.]. Serum PCSK9 Levels Distinguish Individuals Who Do Not Respond to High-Dose Statin Therapy with the Expected Reduction in LDL-C. Journal of Lipids. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-1041047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041047