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Usefulness of Lipid Apheresis in the Treatment of Familial Hypercholesterolemia
Joint Authors
Lui, Matthew
Garberich, Ross
Strauss, Craig
Davin, Thomas
Knickelbine, Thomas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Lipid apheresis is used to treat patients with severe hyperlipidemia by reducing low-density lipoprotein cholesterol (LDL-C).
This study examines the effect of apheresis on the lipid panel and cardiac event rates before and after apheresis.
An electronic health record screen of ambulatory patients identified 11 active patients undergoing lipid apheresis with 10/11 carrying a diagnosis of FH.
Baseline demographics, pre- and postapheresis lipid levels, highest recorded LDL-C, cardiac events, current medications, and first apheresis treatment were recorded.
Patients completed a questionnaire and self-reported risk factors and interest in alternative treatment.
There were significant reductions in mean total cholesterol (−58.4%), LDL-C (−71.9%), triglycerides (−51%), high-density lipoprotein (HDL) cholesterol (−9.3%), and non-HDL (−68.2%) values.
Thirty-four cardiac events were documented in 8 patients before apheresis, compared with 9 events in 5 patients after apheresis.
Our survey showed a high prevalence of statin intolerance (64%), with the majority (90%) of participants indicating an interest in alternative treatment options.
Our results have shown that lipid apheresis primary effect is a marked reduction in LDL-C cholesterol levels and may reduce the recurrence of cardiac events.
Apheresis should be compared to the newer alternative treatment modalities in a randomized fashion due to patient interest in alternative options.
American Psychological Association (APA)
Lui, Matthew& Garberich, Ross& Strauss, Craig& Davin, Thomas& Knickelbine, Thomas. 2014. Usefulness of Lipid Apheresis in the Treatment of Familial Hypercholesterolemia. Journal of Lipids،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1041058
Modern Language Association (MLA)
Lui, Matthew…[et al.]. Usefulness of Lipid Apheresis in the Treatment of Familial Hypercholesterolemia. Journal of Lipids No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1041058
American Medical Association (AMA)
Lui, Matthew& Garberich, Ross& Strauss, Craig& Davin, Thomas& Knickelbine, Thomas. Usefulness of Lipid Apheresis in the Treatment of Familial Hypercholesterolemia. Journal of Lipids. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1041058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041058