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Novel Alginate-Gelatin Hybrid Nanoparticle for Drug Delivery and Tissue Engineering Applications
Joint Authors
Singh, Dolly
Singh, Deepti
Choi, Soon Mo
Han, Sung Soo
Lee, Eun Mi
Zo, Sun Mi
Park, Seon Joo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Novel alginate-gelatin hybrid nanoparticles were fabricated using single oil in water (O/W) emulsification techniques.
Physicochemical property of the particle was characterized using scanning electron microscopy and Fourier’s transmission infrared spectroscopy.
Particle size was determined using zeta potential metastasize analyzer and was found to be in range of 400–600 nm.
AGNPs were used for culturing human keratinocytes for two weeks to check biocompatibility of synthesized AGNPs.
3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed increased metabolic activity of cells cultured on AGNPs in comparison to two-dimensional (2D) system (control).
Cellular attachment on nanoparticle was further confirmed using SEM and 4′,6-diamidino-2-phenylindole staining.
The drug release profile shows possible electrostatic bond between alginate and gelatin resulting in controlled release of drug from AGNPs.
For the first time alginate-gelatin hybrid nanosystem has been fabricated and all results showed it can be used as potential system for delivery of drug and therapeutical agents to cells and can also be used for regenerative medicine applications.
American Psychological Association (APA)
Lee, Eun Mi& Singh, Deepti& Singh, Dolly& Choi, Soon Mo& Zo, Sun Mi& Park, Seon Joo…[et al.]. 2014. Novel Alginate-Gelatin Hybrid Nanoparticle for Drug Delivery and Tissue Engineering Applications. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1041212
Modern Language Association (MLA)
Lee, Eun Mi…[et al.]. Novel Alginate-Gelatin Hybrid Nanoparticle for Drug Delivery and Tissue Engineering Applications. Journal of Nanomaterials No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1041212
American Medical Association (AMA)
Lee, Eun Mi& Singh, Deepti& Singh, Dolly& Choi, Soon Mo& Zo, Sun Mi& Park, Seon Joo…[et al.]. Novel Alginate-Gelatin Hybrid Nanoparticle for Drug Delivery and Tissue Engineering Applications. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1041212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041212