Synthesis and Physicochemical Characterization of Mesoporous SiO2 Nanoparticles
Joint Authors
Das, Dharani
Yang, Yong
O’Brien, Julie S.
Breznan, Dalibor
Nimesh, Surendra
Bernatchez, Stéphane
Hill, Myriam
Sayari, Abdelhamid
Vincent, Renaud
Kumarathasan, Prem
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
There exists a knowledge gap in understanding potential toxicity of mesoporous silica nanoparticles.
A critical step in assessing toxicity of these particles is to have a wide size range with different chemistries and physicochemical properties.
There are several challenges when synthesizing mesoporous silica nanoparticles over a wide range of sizes including (1) nonuniform synthesis protocols using the same starting materials, (2) the low material yield in a single batch synthesis (especially for particles below 60–70 nm), and (3) morphological instability during surfactant removal process and surface modifications.
In this study, we synthesized a library of mesoporous silica nanoparticles with approximate particle sizes of 25, 70, 100, 170, and 600 nm.
Surfaces of the silica nanoparticles were modified with hydrophilic-CH2–(CH2)2–COOH and relatively hydrophobic-CH2–(CH2)10–COOH functional groups.
All silica nanoparticles were analysed for morphology, surface functionality, surface area/pore volume, surface organic content, and dispersion characteristics in liquid media.
Our analysis revealed the synthesis of a spectrum of monodisperse bare and surface modified mesoporous silica nanoparticles with a narrow particle size distribution and devoid of cocontaminants critical for toxicity studies.
Complete physicochemical characterization of these synthetic mesoporous silica nanoparticles will permit systematic toxicology studies for investigation of structure-activity relationships.
American Psychological Association (APA)
Das, Dharani& Yang, Yong& O’Brien, Julie S.& Breznan, Dalibor& Nimesh, Surendra& Bernatchez, Stéphane…[et al.]. 2014. Synthesis and Physicochemical Characterization of Mesoporous SiO2 Nanoparticles. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1041248
Modern Language Association (MLA)
Das, Dharani…[et al.]. Synthesis and Physicochemical Characterization of Mesoporous SiO2 Nanoparticles. Journal of Nanomaterials No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1041248
American Medical Association (AMA)
Das, Dharani& Yang, Yong& O’Brien, Julie S.& Breznan, Dalibor& Nimesh, Surendra& Bernatchez, Stéphane…[et al.]. Synthesis and Physicochemical Characterization of Mesoporous SiO2 Nanoparticles. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1041248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041248