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Synthesis, Characterization, and DNA Binding Studies of Nanoplumbagin
Joint Authors
Pitchumani, Kasi
Shahida Parveen, Sheik Dawood
Affrose, Abdullah
Suresh Kumar, Basuvaraj
Annaraj, Jamespandi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The traditional anticancer medicine plumbagin (PLN) was prepared as nanostructured material (nanoplumbagin, NPn1) from its commercial counterparts, simultaneously coencapsulating with cetyltrimethylammonium bromide or cyclodextrin as stabilizers using ultrasonication technique.
Surface morphology of NPn analysed from atomic force microscopy (AFM) indicates that NPn has tunable size between 75 nm and 100 nm with narrow particle size distribution.
Its binding efficiency with herring sperm DNA was studied using spectral and electrochemical techniques and its efficiency was found to be more compared to the commercial microcrystalline plumbagin (PLN).
DNA cleavage was also studied by gel electrophoresis.
The observed results indicate that NPn1 has better solubility in aqueous medium and hence showed better bioavailability compared to its commercial counterparts.
American Psychological Association (APA)
Shahida Parveen, Sheik Dawood& Affrose, Abdullah& Suresh Kumar, Basuvaraj& Annaraj, Jamespandi& Pitchumani, Kasi. 2014. Synthesis, Characterization, and DNA Binding Studies of Nanoplumbagin. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1041252
Modern Language Association (MLA)
Shahida Parveen, Sheik Dawood…[et al.]. Synthesis, Characterization, and DNA Binding Studies of Nanoplumbagin. Journal of Nanomaterials No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1041252
American Medical Association (AMA)
Shahida Parveen, Sheik Dawood& Affrose, Abdullah& Suresh Kumar, Basuvaraj& Annaraj, Jamespandi& Pitchumani, Kasi. Synthesis, Characterization, and DNA Binding Studies of Nanoplumbagin. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1041252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041252