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Nanocomposites of Polyacrylic Acid Nanogels and Biodegradable Polyhydroxybutyrate for Bone Regeneration and Drug Delivery
Joint Authors
Bergstrand, Anna
Larsson, Anette
Larsson, Mikael
Mesiah, Lilyan
Van Vooren, Celine
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Biodegradable cell scaffolds and local drug delivery to stimulate cell response are currently receiving much scientific attention.
Here we present a nanocomposite that combines biodegradation with controlled release of lithium, which is known to enhance bone growth.
Nanogels of lithium neutralized polyacrylic acid were synthesized by microemulsion-templated polymerization and were incorporated into a biodegradable polyhydroxybutyrate (PHB) matrix.
Nanogel size was characterized using dynamic light scattering, and the nanocomposites were characterized with regard to structure using scanning electron microscopy, mechanical properties using tensile testing, permeability using tritiated water, and lithium release in PBS using a lithium specific electrode.
The nanogels were well dispersed in the composites and the mechanical properties were good, with a decrease in elastic modulus being compensated by increased tolerance to strain in the wet state.
Approximately half of the lithium was released over about three hours, with the remaining fraction being trapped in the PHB for subsequent slow release during biodegradation.
The prepared nanocomposites seem promising for use as dual functional scaffolds for bone regeneration.
Here lithium ions were chosen as model drug, but the nanogels could potentially act as carriers for larger and more complex drugs, possibly while still carrying lithium.
American Psychological Association (APA)
Larsson, Mikael& Bergstrand, Anna& Mesiah, Lilyan& Van Vooren, Celine& Larsson, Anette. 2014. Nanocomposites of Polyacrylic Acid Nanogels and Biodegradable Polyhydroxybutyrate for Bone Regeneration and Drug Delivery. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1041435
Modern Language Association (MLA)
Larsson, Mikael…[et al.]. Nanocomposites of Polyacrylic Acid Nanogels and Biodegradable Polyhydroxybutyrate for Bone Regeneration and Drug Delivery. Journal of Nanomaterials No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1041435
American Medical Association (AMA)
Larsson, Mikael& Bergstrand, Anna& Mesiah, Lilyan& Van Vooren, Celine& Larsson, Anette. Nanocomposites of Polyacrylic Acid Nanogels and Biodegradable Polyhydroxybutyrate for Bone Regeneration and Drug Delivery. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1041435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041435