Characterization and In Vitro Sustained Release of Silibinin from pH Responsive Carbon Nanotube-Based Drug Delivery System
Joint Authors
Arulselvan, Palanisamy
Tan, Julia M.
Karthivashan, Govindarajan
Hussein, Mohd Zobir
Fakurazi, Sharida
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of the present study was to develop and characterize an in vitro sustained release formulation of silibinin (SB) using commercially available carboxylated multiwalled carbon nanotubes (COOH-MWCNTs) and to investigate cytotoxicity action of the synthesized nanohybrid (SB-MWCNTs).
The resulting nanohybrid was characterized with Fourier transform infrared (FTIR), Raman spectroscopy, thermogravimetric analysis (TGA), ultraviolet-visible spectrophotometry (UV-Vis), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).
FTIR, Raman spectroscopy, and TGA analysis confirmed the adsorption of SB molecules to the COOH-MWCNTs.
The release of SB from the COOH-MWCNTs nanocarrier was found to be sustained and pH-dependent.
The maximum percentage release of SB from the nanocarrier reached approximately 96.6% and 43.1% within 1000 minutes when exposed to pH 7.4 and pH 4.8 solutions, respectively.
It was observed that the release of kinetic behaviour of SB from the MWCNTs nanocarrier conformed well to pseudo-second order kinetic model.
The obtained MTT result showed that the SB-MWCNTs exhibited enhanced cytotoxicity to human cancer cell lines in comparison with free SB at lower concentrations.
These results suggest that SB-MWCNTs nanohybrid may be a promising nanodrug delivery system with sustained release property for the treatment of cancers.
American Psychological Association (APA)
Tan, Julia M.& Karthivashan, Govindarajan& Arulselvan, Palanisamy& Fakurazi, Sharida& Hussein, Mohd Zobir. 2014. Characterization and In Vitro Sustained Release of Silibinin from pH Responsive Carbon Nanotube-Based Drug Delivery System. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1041542
Modern Language Association (MLA)
Tan, Julia M.…[et al.]. Characterization and In Vitro Sustained Release of Silibinin from pH Responsive Carbon Nanotube-Based Drug Delivery System. Journal of Nanomaterials No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1041542
American Medical Association (AMA)
Tan, Julia M.& Karthivashan, Govindarajan& Arulselvan, Palanisamy& Fakurazi, Sharida& Hussein, Mohd Zobir. Characterization and In Vitro Sustained Release of Silibinin from pH Responsive Carbon Nanotube-Based Drug Delivery System. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1041542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041542