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Development, Characterization, and Evaluation of PSMA-Targeted Glycol Chitosan Micelles for Prostate Cancer Therapy
Joint Authors
Xu, Jing
Yu, Jingmou
Xu, Xiao
Wang, Liangliang
Liu, Yonghua
Li, Lixin
Zhao, Jianguo
He, Ming
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Prostate cancer-binding peptides- (PCP-) modified polymeric micelles were prepared and used for the treatment of prostate-specific membrane antigen- (PSMA-) expressing prostate cancer in a target-specific manner.
Cholesterol-modified glycol chitosan (CHGC) was synthesized.
PCP-conjugated CHGC (PCP-CHGC) micelles were fabricated and characterized.
The degree of substitution was 5.2 PCP groups and 5.8 cholesterol groups per 100 sugar residues of glycol chitosan.
The critical aggregation concentration (CAC) of PCP-CHGC copolymer was 0.0254 mg/mL.
Doxorubicin (DOX) was chosen as a model antitumor drug.
The DOX-loaded micelles were prepared by an o/w method.
The mean diameter of DOX-loaded PCP-CHGC (DOX-PCP-CHGC) micelles was 293 nm determined by dynamic light scattering (DLS).
DOX released from drug-loaded micelles was in a biphasic manner.
DOX-PCP-CHGC micelles exhibited higher cytotoxicity in vitro against PSMA-expressing LNCaP cells than DOX-loaded CHGC (DOX-CHGC) micelles.
Moreover, the cellular uptake of DOX-PCP-CHGC micelles determined by confocal laser scanning microscopy (CLSM) and flow cytometry was higher than that of DOX-CHGC micelles in LNCaP cells.
Importantly, DOX-PCP-CHGC micelles demonstrated stronger antitumor efficacy against LNCaP tumor xenograft models than doxorubicin hydrochloride and DOX-CHGC micelles.
Taken together, this study provides a potential way in developing PSMA-targeted drug delivery system for prostate cancer therapy.
American Psychological Association (APA)
Xu, Jing& Yu, Jingmou& Xu, Xiao& Wang, Liangliang& Liu, Yonghua& Li, Lixin…[et al.]. 2014. Development, Characterization, and Evaluation of PSMA-Targeted Glycol Chitosan Micelles for Prostate Cancer Therapy. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1041552
Modern Language Association (MLA)
Xu, Jing…[et al.]. Development, Characterization, and Evaluation of PSMA-Targeted Glycol Chitosan Micelles for Prostate Cancer Therapy. Journal of Nanomaterials No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1041552
American Medical Association (AMA)
Xu, Jing& Yu, Jingmou& Xu, Xiao& Wang, Liangliang& Liu, Yonghua& Li, Lixin…[et al.]. Development, Characterization, and Evaluation of PSMA-Targeted Glycol Chitosan Micelles for Prostate Cancer Therapy. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1041552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041552