Hepatocelluar intergrity during sevolurane anesthesia with ainduced hypotension

Abstract EN

The effect of sevoflurane anesthesia with or without induced hypotension on hepatocellular integrity was studied.

Forty adult consented patients scheduled for various urological procedures were allocated randomly to either NTG group (nitroglycerin-induced hypotension) or a control group of twenty patients each.

Anesthesia was induced and maintained by fentanyl, sevoflurane & vecuro¬nium in both groups.

In NTG group, nitro-glycerin infusion was adjusted to maintain mean arterial pressure (MAP) of 50-65 mm Hg.

Specific and sensitive hepatic biomarkers; a (alpha) and % (pi) glutathione S-transferases (GST) and hyaluronic acid (HA), also traditional liver enzymes; aspartate (AST) and ala¬nine (ALT) aminotransferases were measured at: TO (pre-induction), Tl, T2, T3 (15, 30 & 60 minutes after MAP stabilization respectively) and T4 (24 hours after anesthesia end).

Plasma a-GST significantly increased at T3 in con¬trol group (p< 0.05) and in NTG group (p< 0.01) compared to TO in same group.

In NTG group, hyaluronic acid con-centrations was significantly in¬creased at Tl, T2 (p< 0.05) and T3 (p< 0.01) from TO.

Compared to control group, a- GST & HA concentrations showed significant increases in NTG group at T3 with p< 0.05 then returned back to normal range at T4.

But, TT-GST, AST and ALT showed no significant changes throughout the study in both groups