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Application of Gold Nanoparticles for Electrochemical DNA Biosensor
Joint Authors
Mohammed, Ahmed Mishaal
Rahim, Ruslinda A.
Ibraheem, Ibraheem Jaleel
Loong, Foo Kai
Hisham, Hasrul
Hashim, Uda
Al-Douri, Yarub
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
An electrochemical DNA biosensor was successfully fabricated by using (3-aminopropyl)triethoxysilane (APTES) as a linker molecule combined with the gold nanoparticles (GNPs) on thermally oxidized SiO2 thin films.
The SiO2 thin films surface was chemically modified with a mixture of APTES and GNPs for DNA detection in different time periods of 30 min, 1 hour, 2 hours, and 4 hours, respectively.
The DNA immobilization and hybridization were conducted by measuring the differences of the capacitance value within the frequency range of 1 Hz to 1 MHz.
The capacitance values for DNA immobilization were 160 μF, 77.8 μF, 70 μF, and 64.6 μF, respectively, with the period of time from 30 min to 4 hours.
Meanwhile the capacitance values for DNA hybridization were 44 μF, 54 μF, 55 μF, and 61.5 μF, respectively.
The capacitance value of bare SiO2 thin film was 0.42 μF, which was set as a base line for a reference in DNA detection.
The differences of the capacitance value between the DNA immobilization and hybridization revealed that the modified SiO2 thin films using APTES and GNPs were successfully developed for DNA detection.
American Psychological Association (APA)
Mohammed, Ahmed Mishaal& Rahim, Ruslinda A.& Ibraheem, Ibraheem Jaleel& Loong, Foo Kai& Hisham, Hasrul& Hashim, Uda…[et al.]. 2014. Application of Gold Nanoparticles for Electrochemical DNA Biosensor. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1041802
Modern Language Association (MLA)
Mohammed, Ahmed Mishaal…[et al.]. Application of Gold Nanoparticles for Electrochemical DNA Biosensor. Journal of Nanomaterials No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1041802
American Medical Association (AMA)
Mohammed, Ahmed Mishaal& Rahim, Ruslinda A.& Ibraheem, Ibraheem Jaleel& Loong, Foo Kai& Hisham, Hasrul& Hashim, Uda…[et al.]. Application of Gold Nanoparticles for Electrochemical DNA Biosensor. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1041802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041802