![](/images/graphics-bg.png)
The Promotion of Human Neural Stem Cells Adhesion Using Bioinspired Poly(norepinephrine) Nanoscale Coating
Joint Authors
Park, Minah
Shin, Mikyung
Kim, Eunmi
Lee, Slgirim
Park, Kook In
Lee, Haeshin
Jang, Jae-Hyung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The establishment of versatile biomaterial interfaces that can facilitate cellular adhesion is crucial for elucidating the cellular processes that occur on biomaterial surfaces.
Furthermore, biomaterial interfaces can provide physical or chemical cues that are capable of stimulating cellular behaviors by regulating intracellular signaling cascades.
Herein, a method of creating a biomimetic functional biointerface was introduced to enhance human neural stem cell (hNSC) adhesion.
The hNSC-compatible biointerface was prepared by the oxidative polymerization of the neurotransmitter norepinephrine, which generates a nanoscale organic thin layer, termed poly(norepinephrine) (pNE).
Due to its adhesive property, pNE resulted in an adherent layer on various substrates, and pNE-coated biointerfaces provided a highly favorable microenvironment for hNSCs, with no observed cytotoxicity.
Only a 2-hour incubation of hNSCs was required to firmly attach the stem cells, regardless of the type of substrate.
Importantly, the adhesive properties of pNE interfaces led to micropatterns of cellular attachment, thereby demonstrating the ability of the interface to organize the stem cells.
This highly facile surface-modification method using a biomimetic pNE thin layer can be applied to a number of suitable materials that were previously not compatible with hNSC technology.
American Psychological Association (APA)
Park, Minah& Shin, Mikyung& Kim, Eunmi& Lee, Slgirim& Park, Kook In& Lee, Haeshin…[et al.]. 2014. The Promotion of Human Neural Stem Cells Adhesion Using Bioinspired Poly(norepinephrine) Nanoscale Coating. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1041916
Modern Language Association (MLA)
Park, Minah…[et al.]. The Promotion of Human Neural Stem Cells Adhesion Using Bioinspired Poly(norepinephrine) Nanoscale Coating. Journal of Nanomaterials No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1041916
American Medical Association (AMA)
Park, Minah& Shin, Mikyung& Kim, Eunmi& Lee, Slgirim& Park, Kook In& Lee, Haeshin…[et al.]. The Promotion of Human Neural Stem Cells Adhesion Using Bioinspired Poly(norepinephrine) Nanoscale Coating. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1041916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041916