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An Alcohol-Free SiO2 Sol-Gel Matrix Functionalized with Acetic Acid as Drug Reservoir for the Controlled Release of Pentoxifylline
Joint Authors
Alvarez Lemus, M. A.
Castañeda, Oscar Javier Ortiz
Hernández Pérez, Alma Delia
González, Rosendo López
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Pentoxifylline (PTX) is a xanthine derivative, with hemorrheologic properties, that has been useful in the treatment of several diseases.
However, a conventional route of administration implies high doses, what is unnecessary to the organism, seriously increasing the risk of toxicity because of side effects.
Because of the facility to modify their surface, sol-gel materials have proved to be suitable reservoirs for a variety of molecules for biological applications.
In this work we prepared alcohol-free SiO2 material by the sol-gel process using acetic acid as surface modifier and hydrolysis catalyst, the alkoxide/water ratio (Rw) used was 1/16, and tetraethylorthosilicate was used as SiO2 precursor.
Spectroscopic characterization was carried out by means of FTIR-ATR and UV-Visible spectroscopies; the results confirmed the presence of the drug and interactions between sol-gel matrix and PTX.
BET specific surface area values of the sol-gel materials were 365 and 462 m2/g for SiO2 and PTX-SiO2, respectively.
Synthesized SiO2 nanoparticles showed efficient entrapment of PTX since a controlled release of 83% of drug content was reached.
American Psychological Association (APA)
Alvarez Lemus, M. A.& Castañeda, Oscar Javier Ortiz& Hernández Pérez, Alma Delia& González, Rosendo López. 2014. An Alcohol-Free SiO2 Sol-Gel Matrix Functionalized with Acetic Acid as Drug Reservoir for the Controlled Release of Pentoxifylline. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1041988
Modern Language Association (MLA)
Alvarez Lemus, M. A.…[et al.]. An Alcohol-Free SiO2 Sol-Gel Matrix Functionalized with Acetic Acid as Drug Reservoir for the Controlled Release of Pentoxifylline. Journal of Nanomaterials No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1041988
American Medical Association (AMA)
Alvarez Lemus, M. A.& Castañeda, Oscar Javier Ortiz& Hernández Pérez, Alma Delia& González, Rosendo López. An Alcohol-Free SiO2 Sol-Gel Matrix Functionalized with Acetic Acid as Drug Reservoir for the Controlled Release of Pentoxifylline. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1041988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1041988