The Activity of [60]Fullerene Derivatives Bearing Amine and Carboxylic Solubilizing Groups against Escherichia coli: A Comparative Study
Joint Authors
Deryabin, Dmitry
Davydova, Olga K.
Yankina, Zulfiya ZH.
Vasilchenko, Alexey S.
Miroshnikov, Sergei A.
Kornev, Alexey B.
Ivanchikhina, Anastasiya V.
Troshin, Pavel A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We report a comparative investigation of the antibacterial activity of two water-soluble fullerene derivatives bearing protonated amine (AF) and deprotonated carboxylic (CF) groups appended to the fullerene cage via organic linkers.
The negatively charged fullerene derivative CF showed no tendency to bind to the bacterial cells and, consequently, no significant antibacterial activity.
In contrast, the compound AF loaded with cationic groups showed strong and partially irreversible binding to the negatively charged Escherichia coli K12 TG1 cells and to human erythrocytes, also possessing negative zeta potential.
Adsorption of AF on the bacterial surface was visualized by atomic force microscopy revealing the formation of specific clusters (AF aggregates) surrounding the bacterial cell.
Incubation of E.
coli K12 TG1 with AF led to a dose-dependent bactericidal effect with L D 50 = 79.1 µM.
The presence of human erythrocytes in the test medium decreased the AF antibacterial activity.
Thus we reveal that the water-soluble cationic fullerene derivative AF possesses promising antibacterial activity, which might be utilized in the development of novel types of chemical disinfectants.
American Psychological Association (APA)
Deryabin, Dmitry& Davydova, Olga K.& Yankina, Zulfiya ZH.& Vasilchenko, Alexey S.& Miroshnikov, Sergei A.& Kornev, Alexey B.…[et al.]. 2014. The Activity of [60]Fullerene Derivatives Bearing Amine and Carboxylic Solubilizing Groups against Escherichia coli: A Comparative Study. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042024
Modern Language Association (MLA)
Deryabin, Dmitry…[et al.]. The Activity of [60]Fullerene Derivatives Bearing Amine and Carboxylic Solubilizing Groups against Escherichia coli: A Comparative Study. Journal of Nanomaterials No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1042024
American Medical Association (AMA)
Deryabin, Dmitry& Davydova, Olga K.& Yankina, Zulfiya ZH.& Vasilchenko, Alexey S.& Miroshnikov, Sergei A.& Kornev, Alexey B.…[et al.]. The Activity of [60]Fullerene Derivatives Bearing Amine and Carboxylic Solubilizing Groups against Escherichia coli: A Comparative Study. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042024