Fabrication and Characterization of Electrospun Polycaprolactone Blended with Chitosan-Gelatin Complex Nanofibrous Mats
Joint Authors
Qian, Yongfang
Zhang, Zhen
Zheng, Laijiu
Song, Ruoyuan
Zhao, Yuping
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Design and fabrication of nanofibrous scaffolds should mimic the native extracellular matrix.
This study is aimed at investigating electrospinning of polycaprolactone (PCL) blended with chitosan-gelatin complex.
The morphologies were observed from scanning electron microscope.
As-spun blended mats had thinner fibers than pure PCL.
X-ray diffraction was used to analyze the degree of crystallinity.
The intensity at two peaks at 2θ of 21° and 23.5° gradually decreased with the percentage of chitosan-gelatin complex increasing.
Moreover, incorporation of the complex could obviously improve the hydrophilicity of as-spun blended mats.
Mechanical properties of as-spun nanofibrous mats were also tested.
The elongation at break of fibrous mats increased with the PCL content increasing and the ultimate tensile strength varied with different weight ratios.
The as-spun mats had higher tensile strength when the weight ratio of PCL to CS-Gel was 75/25 compared to pure PCL.
Both as-spun PCL scaffolds and PCL/CS-Gel scaffolds supported the proliferation of porcine iliac endothelial cells, and PCL/CS-Gel had better cell viability than pure PCL.
Therefore, electrospun PCL/Chitosan-gelatin nanofibrous mats with weight ratio of 75/25 have better hydrophilicity mechanical properties, and cell proliferation and thus would be a promising candidate for tissue engineering scaffolds.
American Psychological Association (APA)
Qian, Yongfang& Zhang, Zhen& Zheng, Laijiu& Song, Ruoyuan& Zhao, Yuping. 2014. Fabrication and Characterization of Electrospun Polycaprolactone Blended with Chitosan-Gelatin Complex Nanofibrous Mats. Journal of Nanomaterials،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042130
Modern Language Association (MLA)
Qian, Yongfang…[et al.]. Fabrication and Characterization of Electrospun Polycaprolactone Blended with Chitosan-Gelatin Complex Nanofibrous Mats. Journal of Nanomaterials No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042130
American Medical Association (AMA)
Qian, Yongfang& Zhang, Zhen& Zheng, Laijiu& Song, Ruoyuan& Zhao, Yuping. Fabrication and Characterization of Electrospun Polycaprolactone Blended with Chitosan-Gelatin Complex Nanofibrous Mats. Journal of Nanomaterials. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042130