Effects of High Phosphorus Diet on Bone Metabolism-Related Gene Expression in Young and Aged Mice
Joint Authors
Katsumata, Shinichi
Matsuzaki, Hiroshi
Katsumata-Tsuboi, Rie
Uehara, Mariko
Suzuki, Kazuharu
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In this study, the effects of high phosphorus (P) diet on bone metabolism-related gene expression were investigated in young and aged mice.
Twelve- and 80-week-old ddY male mice were divided into two groups, respectively, and fed a control diet containing 0.3% P or a high P diet containing 1.2% P.
After 4 weeks of treatment, serum parathyroid hormone (PTH) concentration was significantly higher in the high P groups than in the control groups in both young and aged mice and was significantly higher in aged mice than in young mice fed the high P diet.
High P diet significantly increased receptor activator of NF-κB ligand (RANKL) mRNA in the femur of both young and aged mice and significantly increased the RANKL/osteoprotegerin (OPG) mRNA ratio only in aged mice.
High P diet significantly increased mRNA expression of transient receptor potential vanilloid type 6, calbindin-D9k, and plasma membrane Ca2+-ATPase 1b in the duodenum of both young and aged mice.
These results suggest that high P diet increased RANKL mRNA expression in the femur and calcium absorption-related gene expression in the duodenum regardless of age.
Furthermore, the high P diet-induced increase in PTH secretion might increase the RANKL/OPG mRNA ratio in aged mice.
American Psychological Association (APA)
Katsumata, Shinichi& Matsuzaki, Hiroshi& Katsumata-Tsuboi, Rie& Uehara, Mariko& Suzuki, Kazuharu. 2014. Effects of High Phosphorus Diet on Bone Metabolism-Related Gene Expression in Young and Aged Mice. Journal of Nutrition and Metabolism،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042165
Modern Language Association (MLA)
Katsumata, Shinichi…[et al.]. Effects of High Phosphorus Diet on Bone Metabolism-Related Gene Expression in Young and Aged Mice. Journal of Nutrition and Metabolism No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042165
American Medical Association (AMA)
Katsumata, Shinichi& Matsuzaki, Hiroshi& Katsumata-Tsuboi, Rie& Uehara, Mariko& Suzuki, Kazuharu. Effects of High Phosphorus Diet on Bone Metabolism-Related Gene Expression in Young and Aged Mice. Journal of Nutrition and Metabolism. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042165
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042165