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Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats
Joint Authors
Singh, Sanjay
Singh, Sanjay Kumar
Singh, Sanjay
Jain, Achint
Vuddanda, Parameswara Rao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Zidovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats.
The aim of this research was to study whether the bioavailability of zidovudine can be improved by AZT-SLNs perorally to rats as compared to oral administration of zidovudine.
Zidovudine was determined in plasma and tissues by reverse phase high performance liquid chromatography.
The pharmacokinetic parameters of zidovudine were determined after peroral administration: area under curve of concentration versus time (AUC) for AZT-SLNs was 31.25% greater than AZT solution; meanwhile mean resident time (MRT) was found to be 1.83 times higher for AZT-SLNs than AZT solution.
Elimination half life of zidovudine was also increased for SLN formulation.
Tissue distribution pattern of zidovudine was changed in case of AZT-SLNs.
AUC of zidovudine in brain and liver was found to be approximately 2.73 and 1.77 times higher in AZT-SLNs than AZT solution, respectively, indicating that AZT-SLNs could cross blood brain barrier.
Distribution of zidovudine was approximately 0.95 and 0.86 times lesser in heart and kidney, respectively.
It can be concluded from the study that oral administration of AZT-SLNs modifies the plasma pharmacokinetic parameters and biodistribution of zidovudine.
American Psychological Association (APA)
Singh, Sanjay& Vuddanda, Parameswara Rao& Singh, Sanjay Kumar& Jain, Achint& Singh, Sanjay. 2014. Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats. Journal of Nanotechnology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042217
Modern Language Association (MLA)
Singh, Sanjay…[et al.]. Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats. Journal of Nanotechnology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042217
American Medical Association (AMA)
Singh, Sanjay& Vuddanda, Parameswara Rao& Singh, Sanjay Kumar& Jain, Achint& Singh, Sanjay. Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats. Journal of Nanotechnology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042217