Prognostic Role of 14F7 Mab Immunoreactivity against N-Glycolyl GM3 Ganglioside in Colon Cancer
Joint Authors
Carr, Adriana
Lahera, Tania
Calvo, Adanays
Torres, Griselda
Quintero, Santiago
Arango, María del Carmen
Danta, Debora
Vázquez, José M.
Rengifo, Charles E.
Escobar, Xiomara
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To assess the prognostic role of 14F7 Mab immunoreactivity, against N-Glycolyl GM3 ganglioside, in patients with colon cancer (CC) and to evaluate the relationship between its expression and clinicopathological features.
Methods.
Paraffin-embedded specimens were retrospectively collected from 50 patients with CC operated between 2004 and 2008.
14F7 Mab staining was determined by immunohistochemistry technique and its relation with survival and clinicopathologic features was evaluated.
Results.
The reactivity of 14F7 Mab was detected in all cases.
Most cases had high level of immunostaining (70%) that showed statistical correlation with TNM stage ( P = 0.025 ) .
In univariate survival analysis, level of 14F7 Mab immunoreactivity ( P = 0.0078 ) , TNM Stage ( P = 0.0007 ) and lymphovascular invasion ( 0.027 ) were significant prognostic factors for overall survival.
Among these variables, level of 14F7 Mab immunoreactivity ( HR = 0 .
268 ; 95 % CI 0 .
078 – 0 .
920 ; P = 0 .
036 ) and TNM stage ( HR = 0 .
249 ; 95 % CI 0 .
066 – 0 .
932 ; P = 0.039 ) were independent prognostic factors on multivariate analysis.
Conclusions.
This study is the first approach on the prognostic significance of 14F7 Mab immunoreactivity in patients with colon adenocarcinoma and this assessment might be used in the prognostic estimate of CC, although further studies will be required to validate these findings.
American Psychological Association (APA)
Lahera, Tania& Calvo, Adanays& Torres, Griselda& Rengifo, Charles E.& Quintero, Santiago& Arango, María del Carmen…[et al.]. 2014. Prognostic Role of 14F7 Mab Immunoreactivity against N-Glycolyl GM3 Ganglioside in Colon Cancer. Journal of Oncology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1042241
Modern Language Association (MLA)
Lahera, Tania…[et al.]. Prognostic Role of 14F7 Mab Immunoreactivity against N-Glycolyl GM3 Ganglioside in Colon Cancer. Journal of Oncology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1042241
American Medical Association (AMA)
Lahera, Tania& Calvo, Adanays& Torres, Griselda& Rengifo, Charles E.& Quintero, Santiago& Arango, María del Carmen…[et al.]. Prognostic Role of 14F7 Mab Immunoreactivity against N-Glycolyl GM3 Ganglioside in Colon Cancer. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1042241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042241