Genomically Driven Precision Medicine to Improve Outcomes in Anaplastic Thyroid Cancer
Joint Authors
Mymryk, Joe S.
Pinto, Nicole
Black, Morgan
Patel, Krupal
Barrett, John W.
Nichols, Anthony C.
Yoo, John
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Thyroid cancer is an endocrine malignancy with an incidence rate that has been increasing steadily over the past 30 years.
While well-differentiated subtypes have a favorable prognosis when treated with surgical resection and radioiodine, undifferentiated subtypes, such as anaplastic thyroid cancer (ATC), are far more aggressive and have a poor prognosis.
Conventional therapies (surgical resection, radiation, chemotherapy, and radioiodine) have been utilized for treatment of ATC, yet these treatments have not significantly improved the overall mortality rate.
As cancer is a genetic disease, genetic alterations such as mutations, fusions, activation of oncogenes, and silencing of tumor suppressors contribute to its aggressiveness.
With the use of next-generation sequencing and the Cancer Genome Atlas, mutation-directed therapy is recognized as the upcoming standard of care.
In this review, we highlight the known genetic landscape of ATC and the need for a comprehensive genetic characterization of this disease in order to identify additional therapeutic targets to improve patient outcomes.
American Psychological Association (APA)
Pinto, Nicole& Black, Morgan& Patel, Krupal& Yoo, John& Mymryk, Joe S.& Barrett, John W.…[et al.]. 2014. Genomically Driven Precision Medicine to Improve Outcomes in Anaplastic Thyroid Cancer. Journal of Oncology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042289
Modern Language Association (MLA)
Pinto, Nicole…[et al.]. Genomically Driven Precision Medicine to Improve Outcomes in Anaplastic Thyroid Cancer. Journal of Oncology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042289
American Medical Association (AMA)
Pinto, Nicole& Black, Morgan& Patel, Krupal& Yoo, John& Mymryk, Joe S.& Barrett, John W.…[et al.]. Genomically Driven Precision Medicine to Improve Outcomes in Anaplastic Thyroid Cancer. Journal of Oncology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042289