![](/images/graphics-bg.png)
Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery
Joint Authors
Lapointe, Marc
Rezvani, Reza
Smith, Jessica
Marceau, Picard
Tchernof, André
Cianflone, Katherine
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
Obesity is associated with metabolic dysfunction with sex differences and chronic, low-grade inflammation.
We proposed that hepatic expression of immune complement C3 related receptors (C3aR, C5aR, and C5L2) would be associated with pre- or postmenopausal status and metabolic profile in severely obese women.
We hypothesized that C5L2/C5aR ratio, potentially influencing the ASP/C5L2 metabolic versus C5a/C5aR immune response, would predict metabolic profiles after weight loss surgery.
Materials and Methods.
Fasting plasma (hormone, lipid, and enzyme analysis) and liver biopsies (RT-PCR gene expression) were obtained from 91 women during surgery.
Results.
Hepatic C5L2 mRNA expression was elevated in pre- versus postmenopausal women ( P < 0.01 ) and correlated positively with circulating estradiol, estrone, ApoB, ApoA1, ApoA1/B, waist circumference, age, and LDL-C (all P < 0.05 ).
While plasma ASP was lower in pre- versus postmenopausal women ( P < 0.01 ), the hepatic C5L2/C5aR mRNA ratio was increased ( P < 0.001 ) and correlated positively with estrone ( P < 0.01 ) and estradiol ( P < 0.001 ) and negatively with circulating ApoB and liver enzymes ALT, AST, and GGT (all P < 0.05 ).
Over 12 months postoperatively, liver enzymes in low C5L2/C5aR mRNA ratio group remained higher (ALP and ALT, P < 0.05 , AST and GGT, P < 0.001 2-way-ANOVA).
Conclusion.
C5L2-C5aR association with other mediators including estrogens may contribute to hepatic metabolic and inflammatory function.
American Psychological Association (APA)
Rezvani, Reza& Smith, Jessica& Lapointe, Marc& Marceau, Picard& Tchernof, André& Cianflone, Katherine. 2014. Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery. Journal of Obesity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1042347
Modern Language Association (MLA)
Rezvani, Reza…[et al.]. Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery. Journal of Obesity No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1042347
American Medical Association (AMA)
Rezvani, Reza& Smith, Jessica& Lapointe, Marc& Marceau, Picard& Tchernof, André& Cianflone, Katherine. Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery. Journal of Obesity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1042347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042347