High Fat Diet Induces Adhesion of Platelets to Endothelium in Two Models of Dyslipidemia
Joint Authors
Donoso, W.
Gonzalez, Jaime
Díaz, Natalia
Albornoz, María Eliana
Huilcaman, Ricardo
Morales, Erik
Moore-Carrasco, Rodrigo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cardiovascular diseases (CVD) represent about 30% of all global deaths.
It is currently accepted that, in the atherogenic process, platelets play an important role, contributing to endothelial activation and modulation of the inflammatory phenomenon, promoting the beginning and formation of lesions and their subsequent thrombotic complications.
The objective of the present work was to study using immunohistochemistry, the presence of platelets, monocytes/macrophages, and cell adhesion molecules (CD61, CD163, and CD54), in two stages of the atheromatous process.
CF-1 mice fed a fat diet were used to obtain early stages of atheromatous process, denominated early stage of atherosclerosis, and ApoE−/− mice fed a fat diet were used to observe advanced stages of atherosclerosis.
The CF-1 mice model presented immunostaining on endothelial surface for all three markers studied; the advanced atherosclerosis model in ApoE−/− mice also presented granular immunostaining on lesion thickness, for the same markers.
These results suggest that platelets participate in atheromatous process from early stages to advance d stages.
High fat diet induces adhesion of platelets to endothelial cells in vivo.
These findings support studying the participation of platelets in the formation of atheromatous plate.
American Psychological Association (APA)
Gonzalez, Jaime& Donoso, W.& Díaz, Natalia& Albornoz, María Eliana& Huilcaman, Ricardo& Morales, Erik…[et al.]. 2014. High Fat Diet Induces Adhesion of Platelets to Endothelium in Two Models of Dyslipidemia. Journal of Obesity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042369
Modern Language Association (MLA)
Gonzalez, Jaime…[et al.]. High Fat Diet Induces Adhesion of Platelets to Endothelium in Two Models of Dyslipidemia. Journal of Obesity No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042369
American Medical Association (AMA)
Gonzalez, Jaime& Donoso, W.& Díaz, Natalia& Albornoz, María Eliana& Huilcaman, Ricardo& Morales, Erik…[et al.]. High Fat Diet Induces Adhesion of Platelets to Endothelium in Two Models of Dyslipidemia. Journal of Obesity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042369