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Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes
Joint Authors
Robubi, Armin
Huber, Klaus R.
Krugluger, Walter
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Fructose in excessive amounts exerts negative effects on insulin sensitivity, blood pressure, and liver metabolism.
These adverse outcomes were attributed to its disturbances of key metabolic pathways in the liver.
Recently, possible consequences of high fructose levels directly on adipocytes in vivo have been considered.
We have cultured adipocytes in growth media containing 1 g/L fructose additionally to glucose and monitored the cells fate.
Cells developed lipid vesicles much earlier with fructose and showed altered kinetics of the expression of mRNAs involved in lipogenesis and hexose uptake.
Adiponectin secretion, too, peaked earlier in fructose containing media than in media with glucose only.
From these data it can be speculated that similar effects of fructose containing diets happen in vivo also.
Apart from toxic action on liver cells, adipocytes might be stimulated to take up extra fructose and generate new lipid vesicles, further dysregulating energy homeostasis.
American Psychological Association (APA)
Robubi, Armin& Huber, Klaus R.& Krugluger, Walter. 2014. Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes. Journal of Obesity،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042378
Modern Language Association (MLA)
Robubi, Armin…[et al.]. Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes. Journal of Obesity No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1042378
American Medical Association (AMA)
Robubi, Armin& Huber, Klaus R.& Krugluger, Walter. Extra Fructose in the Growth Medium Fuels Lipogenesis of Adipocytes. Journal of Obesity. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1042378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042378