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Effects of Obesity on Bone Mass and Quality in Ovariectomized Female Zucker Rats
Joint Authors
Feresin, Rafaela G.
Jo, Edward
Hakkak, Reza
Arjmandi, Bahram H.
Elam, Marcus L.
Johnson, Sarah A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Obesity and osteoporosis are two chronic conditions that have been increasing in prevalence.
Despite prior data supporting the positive relationship between body weight and bone mineral density (BMD), recent findings show excess body weight to be detrimental to bone mass, strength, and quality.
To evaluate whether obesity would further exacerbate the effects of ovariectomy on bone, we examined the tibiae and fourth lumbar (L4) vertebrae from leptin receptor-deficient female ( L e p r f a / f a ) Zucker rats and their heterozygous lean controls ( L e p r f a / + ) that were either sham-operated or ovariectomized (Ovx).
BMD of L4 vertebra was measured using dual-energy X-ray absorptiometry, and microcomputed tomography was used to assess the microstructural properties of the tibiae.
Ovariectomy significantly ( P < 0.001 ) decreased the BMD of L4 vertebrae in lean and obese Zucker rats.
Lower trabecular number and greater trabecular separation ( P < 0.001 ) were also observed in the tibiae of lean- and obese-Ovx rats when compared to sham rats.
However, only the obese-Ovx rats had lower trabecular thickness (Tb.Th) ( P < 0.005 ) than the other groups.
These findings demonstrated that ovarian hormone deficiency adversely affected bone mass and quality in lean and obese rats while obesity only affected Tb.Th in Ovx-female Zucker rats.
American Psychological Association (APA)
Feresin, Rafaela G.& Johnson, Sarah A.& Elam, Marcus L.& Jo, Edward& Arjmandi, Bahram H.& Hakkak, Reza. 2014. Effects of Obesity on Bone Mass and Quality in Ovariectomized Female Zucker Rats. Journal of Obesity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042380
Modern Language Association (MLA)
Feresin, Rafaela G.…[et al.]. Effects of Obesity on Bone Mass and Quality in Ovariectomized Female Zucker Rats. Journal of Obesity No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042380
American Medical Association (AMA)
Feresin, Rafaela G.& Johnson, Sarah A.& Elam, Marcus L.& Jo, Edward& Arjmandi, Bahram H.& Hakkak, Reza. Effects of Obesity on Bone Mass and Quality in Ovariectomized Female Zucker Rats. Journal of Obesity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042380