Treatment of Corneal Neovascularization Using Anti-VEGF Bevacizumab
Joint Authors
Vokrojova, Magdalena
Studeny, Pavel
Liehneova, Katerina
Sivekova, Deli
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Purpose.
To evaluate antiangiogenic effect of local use of bevacizumab (anti-VEGF antibody) in patients with corneal neovascularization.
Methods.
Patients were divided into two groups.
All patients suffered from some form of corneal neovascularization (NV).
Patients in group A received 0.2–0.5 mL of bevacizumab solution subconjunctivally (concentration 25 mg/mL) in a single dose.
Group A included 28 eyes from 27.
Patients in group B applied bevacizumab eye drops twice daily (concentration 2.5 mg/mL) for two weeks.
Group B included 38 eyes from 35 patients.
We evaluated the number of corneal segments affected by NV, CDVA, and the incidence of complications and subjective complaints related to the treatment.
The minimum follow-up period was six months.
Results.
By the 6-month follow-up, in group A the percentage reduction of the affected peripheral segments was 21.6% and of the central segments was 9.6%; in group B the percentage reduction of the central segments was 22.7% and of the central segments was 38.04%.
In both groups we noticed a statistically significant reduction in the extent of NV.
Conclusion.
The use of bevacizumab seems to be an effective and safe method in the treatment of corneal neovascularization, either in the subconjunctival or topical application form.
American Psychological Association (APA)
Sivekova, Deli& Vokrojova, Magdalena& Liehneova, Katerina& Studeny, Pavel. 2014. Treatment of Corneal Neovascularization Using Anti-VEGF Bevacizumab. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042420
Modern Language Association (MLA)
Sivekova, Deli…[et al.]. Treatment of Corneal Neovascularization Using Anti-VEGF Bevacizumab. Journal of Ophthalmology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042420
American Medical Association (AMA)
Sivekova, Deli& Vokrojova, Magdalena& Liehneova, Katerina& Studeny, Pavel. Treatment of Corneal Neovascularization Using Anti-VEGF Bevacizumab. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042420