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The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study
Joint Authors
Altun, Ahmet
Acikgoz, Semih
Ozbay, Nurver
Sengor, Tomris
Olcaysu, Osman Okan
Kurna, S. A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
The aim was to compare the effects of antiglaucoma eye drops on the tear functions and ocular surface.
Method.
Eighty-five eyes of 43 patients with glaucoma were included into this randomized prospective study.
Timolol without preservative (1), timolol with benzododecinium bromide (2), latanoprost (3), bimatoprost (4), travoprost with benzalkonium chloride (5), and brimonidine with purite (6) were given to 6 groups.
Schirmer I, tear film breakup time (TBUT), staining scores, and impression cytology samples were evaluated before and during 12-month-follow-up period.
Results.
At the end of 12 months, there was no detected change in Schirmer I and TBUT tests indicating dry eye.
Corneal staining scores were higher in groups 1 and 2, while conjunctival staining scores were higher in group 6.
Goblet cell count decreased in groups 1 and 5 in superior and inferior, group 2 in superior, and groups 3 and 6 in inferior conjunctiva.
Squamous metaplasia grades showed a significant increase in groups 1 and 2 at 3rd, 6th, and 12th month controls ( P < 0.05 ).
Conclusion.
We observed nonserious impact on tear functions and ocular surface with antiglaucoma monotherapy.
Beta blockers induced more damage on the ocular surface suggesting the role of the dosing and active substances beside preservatives.
American Psychological Association (APA)
Kurna, S. A.& Acikgoz, Semih& Altun, Ahmet& Ozbay, Nurver& Sengor, Tomris& Olcaysu, Osman Okan. 2014. The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1042517
Modern Language Association (MLA)
Sengor, Tomris…[et al.]. The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study. Journal of Ophthalmology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1042517
American Medical Association (AMA)
Kurna, S. A.& Acikgoz, Semih& Altun, Ahmet& Ozbay, Nurver& Sengor, Tomris& Olcaysu, Osman Okan. The Effects of Topical Antiglaucoma Drugs as Monotherapy on the Ocular Surface: A Prospective Study. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1042517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042517