Investigation of PACAP Fragments and Related Peptides in Chronic Retinal Hypoperfusion
Joint Authors
Werling, Dora
Reglodi, Dora
Kiss, Peter
Toth, Gabor
Szabadfi, Krisztina
Tamas, Andrea
Biro, Zsolt
Atlasz, Tamas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pituitary adenylate cyclase activating polypeptide (PACAP) has neuroprotective effects in different neuronal and retinal injuries.
Retinal ischemia can be effectively modelled by permanent bilateral common carotid artery occlusion (BCCAO), which causes chronic hypoperfusion-induced degeneration in the entire rat retina.
The retinoprotective effect of PACAP 1-38 and VIP is well-established in ischemic retinopathy.
However, little is known about the effects of related peptides and PACAP fragments in ischemic retinopathy.
The aim of the present study was to investigate the potential retinoprotective effects of different PACAP fragments (PACAP 4-13, 4-22, 6-10, 6-15, 11-15, and 20-31) and related peptides (secretin, glucagon) in BCCAO-induced ischemic retinopathy.
Wistar rats (3-4 months old) were used in the experiment.
After performing BCCAO, the right eyes of the animals were treated with PACAP fragments or related peptides intravitreal (100 pM), while the left eyes were injected with saline serving as control eyes.
Sham-operated (without BCCAO) rats received the same treatment.
Routine histology was performed 2 weeks after the surgery; cells were counted and the thickness of retinal layers was compared.
Our results revealed significant neuroprotection by PACAP 1-38 but did not reveal retinoprotective effect of the PACAP fragments or related peptides.
These results suggest that PACAP 1-38 has the greatest efficacy in ischemic retinopathy.
American Psychological Association (APA)
Werling, Dora& Reglodi, Dora& Kiss, Peter& Toth, Gabor& Szabadfi, Krisztina& Tamas, Andrea…[et al.]. 2014. Investigation of PACAP Fragments and Related Peptides in Chronic Retinal Hypoperfusion. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042576
Modern Language Association (MLA)
Werling, Dora…[et al.]. Investigation of PACAP Fragments and Related Peptides in Chronic Retinal Hypoperfusion. Journal of Ophthalmology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042576
American Medical Association (AMA)
Werling, Dora& Reglodi, Dora& Kiss, Peter& Toth, Gabor& Szabadfi, Krisztina& Tamas, Andrea…[et al.]. Investigation of PACAP Fragments and Related Peptides in Chronic Retinal Hypoperfusion. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042576