The Anti-Acetylcholine Receptor Antibody Test in Suspected Ocular Myasthenia Gravis

Abstract EN

Aim.

To estimate the clinical significance of anti-acetylcholine receptor antibody (anti-AChR-Ab) levels in suspected ocular myasthenia gravis.

Methods.

In total, 144 patients complaining of fluctuating diplopia and ptosis were evaluated for serum levels of anti-acetylcholine receptor antibody and their medical charts were retrospectively reviewed.

Subjects were classified into three groups: variable diplopia only, ptosis only, and both variable diplopia and ptosis.

We investigated serum anti-AChR-Ab titer levels and performed thyroid autoantibody tests.

Results.

Patients’ chief complaints were diplopia (N=103), ptosis (N=12), and their concurrence (N=29).

Abnormal anti-AChR-Ab was observed in 21 of 144 patients (14.1%).

Between the three groups, mean age, number of seropositive patients, and mean anti-AChR-Ab level were not significantly different (P=0.224, 0.073, and 0.062, resp.).

Overall, 27.5% of patients had abnormal thyroid autoantibodies.

Conclusion.

The sensitivity of anti-AChR-Ab was 14.1% in suspected ocular myasthenia gravis and seropositivity in myasthenia gravis patients showed a high correlation with the presence of thyroid autoantibodies.