The Role of Microglia in Diabetic Retinopathy
Joint Authors
Tsin, Andrew T. C.
Cardona, Sandra M.
Pouw, Cindy E.
Muniz, Alberto
Mendiola, Andrew S.
Allen, Donald M.
Cardona, Astrid E.
Grigsby, Jeffery
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
There is growing evidence that chronic inflammation plays a role in both the development and progression of diabetic retinopathy.
There is also evidence that molecules produced as a result of hyperglycemia can activate microglia.
However the exact contribution of microglia, the resident immune cells of the central nervous system, to retinal tissue damage during diabetes remains unclear.
Current data suggest that dysregulated microglial responses are linked to their deleterious effects in several neurological diseases associated with chronic inflammation.
As inflammatory cytokines and hyperglycemia disseminate through the diabetic retina, microglia can change to an activated state, increase in number, translocate through the retina, and themselves become the producers of inflammatory and apoptotic molecules or alternatively exert anti-inflammatory effects.
In addition, microglial genetic variations may account for some of the individual differences commonly seen in patient’s susceptibility to diabetic retinopathy.
American Psychological Association (APA)
Grigsby, Jeffery& Cardona, Sandra M.& Pouw, Cindy E.& Muniz, Alberto& Mendiola, Andrew S.& Tsin, Andrew T. C.…[et al.]. 2014. The Role of Microglia in Diabetic Retinopathy. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1042599
Modern Language Association (MLA)
Grigsby, Jeffery…[et al.]. The Role of Microglia in Diabetic Retinopathy. Journal of Ophthalmology No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1042599
American Medical Association (AMA)
Grigsby, Jeffery& Cardona, Sandra M.& Pouw, Cindy E.& Muniz, Alberto& Mendiola, Andrew S.& Tsin, Andrew T. C.…[et al.]. The Role of Microglia in Diabetic Retinopathy. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1042599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042599