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The Role of Epigenetics in the Fibrotic Processes Associated with Glaucoma
Joint Authors
McDonnell, Fiona
Wallace, Deborah
O'Brien, Colm
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Glaucoma is an optic neuropathy that affects 60 million people worldwide.
The main risk factor for glaucoma is increased intraocular pressure (IOP), this is currently the only target for treatment of glaucoma.
However, some patients show disease progression despite well-controlled IOP.
Another possible therapeutic target is the extracellular matrix (ECM) changes in glaucoma.
There is an accumulation of ECM in the lamina cribrosa (LC) and trabecular meshwork (TM) and upregulation of profibrotic factors such as transforming growth factor β (TGFβ), collagen1α1 (COL1A1), and α-smooth muscle actin (αSMA).
One method of regulating fibrosis is through epigenetics; the study of heritable changes in gene function caused by mechanisms other than changes in the underlying DNA sequence.
Epigenetic mechanisms have been shown to drive renal and pulmonary fibrosis by upregulating profibrotic factors.
Hypoxia alters epigenetic mechanisms through regulating the cell’s response and there is a hypoxic environment in the LC and TM in glaucoma.
This review looks at the role that hypoxia plays in inducing aberrant epigenetic mechanisms and the role these mechanisms play in inducing fibrosis.
Evidence suggests that a hypoxic environment in glaucoma may induce aberrant epigenetic mechanisms that contribute to disease fibrosis.
These may prove to be relevant therapeutic targets in glaucoma.
American Psychological Association (APA)
McDonnell, Fiona& O'Brien, Colm& Wallace, Deborah. 2014. The Role of Epigenetics in the Fibrotic Processes Associated with Glaucoma. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042611
Modern Language Association (MLA)
McDonnell, Fiona…[et al.]. The Role of Epigenetics in the Fibrotic Processes Associated with Glaucoma. Journal of Ophthalmology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1042611
American Medical Association (AMA)
McDonnell, Fiona& O'Brien, Colm& Wallace, Deborah. The Role of Epigenetics in the Fibrotic Processes Associated with Glaucoma. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1042611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042611