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Cell Models to Study Regulation of Cell Transformation in Pathologies of Retinal Pigment Epithelium
Joint Authors
Kuznetsova, Alla V.
Kurinov, Alexander M.
Aleksandrova, Maria A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
The retinal pigment epithelium (RPE) plays a key role in the development of many eye diseases leading to visual impairment and even blindness.
Cell culture models of pathological changes in the RPE make it possible to study factors responsible for these changes and signaling pathways coordinating cellular and molecular mechanisms of cell interactions under pathological conditions.
Moreover, they give an opportunity to reveal target cells and develop effective specific treatment for degenerative and dystrophic diseases of the retina.
In this review, data are presented on RPE cell sources for culture models, approaches to RPE cell culturing, phenotypic changes of RPE cells in vitro, the role of signal pathways, and possibilities for their regulation in pathological processes.
American Psychological Association (APA)
Kuznetsova, Alla V.& Kurinov, Alexander M.& Aleksandrova, Maria A.. 2014. Cell Models to Study Regulation of Cell Transformation in Pathologies of Retinal Pigment Epithelium. Journal of Ophthalmology،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1042622
Modern Language Association (MLA)
Kuznetsova, Alla V.…[et al.]. Cell Models to Study Regulation of Cell Transformation in Pathologies of Retinal Pigment Epithelium. Journal of Ophthalmology No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1042622
American Medical Association (AMA)
Kuznetsova, Alla V.& Kurinov, Alexander M.& Aleksandrova, Maria A.. Cell Models to Study Regulation of Cell Transformation in Pathologies of Retinal Pigment Epithelium. Journal of Ophthalmology. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1042622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042622