The Combination Therapy with Zoledronic Acid and Propranolol Improves the Trabecular Microarchitecture and Mechanical Property in an Rat Model of Postmenopausal Osteoporosis
Joint Authors
Khajuria, Deepak Kumar
Razdan, Rema
Mahapatra, D. Roy
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We conducted the present study to investigate the therapeutic effects of propranolol (PRO), alone and in combination with the antiresorptive agent ZOL, in a rat model of postmenopausal osteoporosis.
Female Wistar rats were OVX or sham-operated at 3 months of age.
Twelve weeks after surgery, rats were randomized into six groups: (1) sham + vehicle, (2) OVX + vehicle, (3) OVX + ZOL (100 μg/kg, i.v.
single dose), (4) OVX + ZOL (50 μg/kg, i.v.
single dose), (5) OVX + PRO (0.1 mg/kg, s.c.
5 days per week), and (6) OVX + ZOL (50 μg/kg, i.v.
single dose) + PRO (0.1 mg/kg, s.c.
5 days per week) for 12 weeks.
At the end of treatment study, various bone parameters were evaluated.
With respect to improvement in the mechanical strength of the lumbar spine and the femoral mid-shaft, the combination treatment of ZOL and PRO was more effective than each drug administered as a monotherapy.
Moreover, combination therapy using ZOL and PRO preserved the trabecular microarchitecture better than single-drug therapy using ZOL or PRO in OVX rats.
These data suggest that combination therapy with ZOL plus PRO represents a potentially useful therapeutic option for patients with osteoporosis.
American Psychological Association (APA)
Khajuria, Deepak Kumar& Razdan, Rema& Mahapatra, D. Roy. 2014. The Combination Therapy with Zoledronic Acid and Propranolol Improves the Trabecular Microarchitecture and Mechanical Property in an Rat Model of Postmenopausal Osteoporosis. Journal of Osteoporosis،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1042699
Modern Language Association (MLA)
Khajuria, Deepak Kumar…[et al.]. The Combination Therapy with Zoledronic Acid and Propranolol Improves the Trabecular Microarchitecture and Mechanical Property in an Rat Model of Postmenopausal Osteoporosis. Journal of Osteoporosis No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1042699
American Medical Association (AMA)
Khajuria, Deepak Kumar& Razdan, Rema& Mahapatra, D. Roy. The Combination Therapy with Zoledronic Acid and Propranolol Improves the Trabecular Microarchitecture and Mechanical Property in an Rat Model of Postmenopausal Osteoporosis. Journal of Osteoporosis. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1042699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042699