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Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2 (300,000 IU)
Joint Authors
Sankaralingam, A.
Roplekar, R.
Turner, C.
Dalton, R. N.
Hampson, G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Vitamin D is important for bone health, although high loading doses have been associated with an increase in fracture risk.
The mechanisms remain uncertain.
Aim.
We hypothesize that supraphysiological concentrations of 1,25 (OH)2 vitamin D may inhibit formation by increasing the production of Wnt inhibitors: sclerostin and DKK1.
Subjects and Methods.
We measured serum sclerostin and DKK1 in 34 patients (21 F, 13 M) aged mean (SD) 61.3 (15.6) years with vitamin D deficiency/insufficiency treated with a loading dose of vitamin D2 (300,000 IU) intramuscularly.
Blood samples were taken at baseline and serially up to 3 months.
Results.
Serum 1,25 (OH)2 vitamin D increased markedly at 3 months (mean (SD) baseline 116 (63), 3 months : 229 (142) pmol/L, P<0.001).
There was a significant correlation between sclerostin and DKK1 at baseline (r=0.504, P=0.002) and at 3 months (r=0.42, P=0.013).
A significant inverse correlation was observed between sclerostin and eGFR at 3 months (r=-0.494, P=0.007).
Sclerostin increased significantly at 3 months (P=0.033).
In a multilinear regression analysis with % change in sclerostin and DKK1 as dependent variable, a positive significant association was observed with % change in 1,25 (OH)2 vitamin D (P=0.038), independent of changes in PTH and following correction for confounders such as age, gender, BMI, BMD and eGFR.
Conclusions.
Supraphysiological concentration in 1,25 (OH)2 vitamin D achieved following a loading dose of vitamin D increases sclerostin and may inhibit Wnt signalling.
This may have detrimental effects on bone.
American Psychological Association (APA)
Sankaralingam, A.& Roplekar, R.& Turner, C.& Dalton, R. N.& Hampson, G.. 2014. Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2 (300,000 IU). Journal of Osteoporosis،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042703
Modern Language Association (MLA)
Sankaralingam, A.…[et al.]. Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2 (300,000 IU). Journal of Osteoporosis No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042703
American Medical Association (AMA)
Sankaralingam, A.& Roplekar, R.& Turner, C.& Dalton, R. N.& Hampson, G.. Changes in Dickkopf-1 (DKK1) and Sclerostin following a Loading Dose of Vitamin D2 (300,000 IU). Journal of Osteoporosis. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042703