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Latency after Preterm Prelabor Rupture of the Membranes: Increased Risk for Periventricular Leukomalacia
Joint Authors
Denzler, Annick
Burkhardt, Tilo
Natalucci, Giancarlo
Zimmermann, Roland
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To identify the risk factors for cystic periventricular leukomalacia (cPVL) and their implications for deciding between immediate delivery and conservative management of preterm prelabor rupture of the membranes (pPROM).
Methods.
The following risk factors were compared between cPVL infants and 6440 controls: chorioamnionitis, sex, gestational age (GA), birth weight, pPROM, and pPROM-delivery interval.
Factor impact on cPVL risk and clinical decision-making was determined by multivariate logistic regression.
Results.
Overall cPVL prevalence ( n = 32 ) was 0.99/1000 births.
All cPVL infants but one were born <34 weeks of gestation and were <2500 g; 56% had histological chorioamnionitis versus 1.1% of controls (OR 35.9; 95%-CI 12.6–102.7).
Because chorioamnionitis is a postnatal diagnosis, logistic regression was performed with prenatally available factors: pPROM-delivery interval >48 hours (OR 9.0; 95%-CI 4.1–20.0), male gender (OR 3.2; 95%-CI 1.4–7.3).
GA was not a risk factor if birth weight was included.
Risk decreased with increasing fetal weight despite a prolonged pPROM-delivery interval.
Conclusion.
pPROM-delivery interval is the single most important prenatally available risk factor for the development of cPVL.
Immediate delivery favors babies with chorioamnionitis but disfavors those with non infectious pPROM.
In the absence of clinical chorioamnionitis fetal weight gain may offset the inflammatory risk of cPVL caused by a prolonged pPROM-delivery interval.
American Psychological Association (APA)
Denzler, Annick& Burkhardt, Tilo& Natalucci, Giancarlo& Zimmermann, Roland. 2014. Latency after Preterm Prelabor Rupture of the Membranes: Increased Risk for Periventricular Leukomalacia. Journal of Pregnancy،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042736
Modern Language Association (MLA)
Denzler, Annick…[et al.]. Latency after Preterm Prelabor Rupture of the Membranes: Increased Risk for Periventricular Leukomalacia. Journal of Pregnancy No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1042736
American Medical Association (AMA)
Denzler, Annick& Burkhardt, Tilo& Natalucci, Giancarlo& Zimmermann, Roland. Latency after Preterm Prelabor Rupture of the Membranes: Increased Risk for Periventricular Leukomalacia. Journal of Pregnancy. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1042736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042736