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Antihemolytic Activities of Green Tea, Safflower, and Mulberry Extracts during Plasmodium berghei Infection in Mice
Joint Authors
Audomkasok, Suthin
Singpha, Waraporn
Chachiyo, Sukanya
Somsak, Voravuth
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Malaria-associated hemolysis is associated with mortality in adult patients.
It has been speculated that oxidative stress and inflammation induced by malaria parasite are involved in its pathophysiology.
Hence, we aimed to investigate the antihemolytic effect of green tea, safflower, and mulberry extracts against Plasmodium berghei infection.
Aqueous crude extracts of these plants were prepared using hot water method and used for oral treatment in mice.
Groups of ICR mice were infected with 6 × 106 infected red blood cells of P.
berghei ANKA by intraperitoneal injection and given the extracts (500, 1500, and 3000 mg/kg) twice a day for 4 consecutive days.
To assess hemolysis, hematocrit levels were then evaluated.
Malaria infection resulted in hemolysis.
However, antihemolytic effects were observed in infected mice treated with these extracts at dose-dependent manners.
In conclusion, aqueous crude extracts of green tea, safflower, and mulberry exerted antihemolysis induced by malaria infection.
These plants may work as potential source in the development of variety of herbal formulations for malarial treatment.
American Psychological Association (APA)
Audomkasok, Suthin& Singpha, Waraporn& Chachiyo, Sukanya& Somsak, Voravuth. 2014. Antihemolytic Activities of Green Tea, Safflower, and Mulberry Extracts during Plasmodium berghei Infection in Mice. Journal of Pathogens،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1042759
Modern Language Association (MLA)
Audomkasok, Suthin…[et al.]. Antihemolytic Activities of Green Tea, Safflower, and Mulberry Extracts during Plasmodium berghei Infection in Mice. Journal of Pathogens No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1042759
American Medical Association (AMA)
Audomkasok, Suthin& Singpha, Waraporn& Chachiyo, Sukanya& Somsak, Voravuth. Antihemolytic Activities of Green Tea, Safflower, and Mulberry Extracts during Plasmodium berghei Infection in Mice. Journal of Pathogens. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1042759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042759