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Type I Diabetes Mellitus: Genetic Factors and Presumptive Enteroviral Etiology or Protection
Joint Authors
Precechtelova, Jana
Borsanyiova, Maria
Sarmirova, Sona
Bopegamage, Shubhada
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-10
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
We review type 1 diabetes and host genetic components, as well as epigenetics and viruses associated with type 1 diabetes, with added emphasis on the enteroviruses, which are often associated with triggering the disease.
Genus Enterovirus is classified into twelve species of which seven (Enterovirus A, Enterovirus B, Enterovirus C, and Enterovirus D and Rhinovirus A, Rhinovirus B, and Rhinovirus C) are human pathogens.
These viruses are transmitted mainly by the fecal-oral route; they may also spread via the nasopharyngeal route.
Enterovirus infections are highly prevalent, but these infections are usually subclinical or cause a mild flu-like illness.
However, infections caused by enteroviruses can sometimes be serious, with manifestations of meningoencephalitis, paralysis, myocarditis, and in neonates a fulminant sepsis-like syndrome.
These viruses are often implicated in chronic (inflammatory) diseases as chronic myocarditis, chronic pancreatitis, and type 1 diabetes.
In this review we discuss the currently suggested mechanisms involved in the viral induction of type 1 diabetes.
We recapitulate current basic knowledge and definitions.
American Psychological Association (APA)
Precechtelova, Jana& Borsanyiova, Maria& Sarmirova, Sona& Bopegamage, Shubhada. 2014. Type I Diabetes Mellitus: Genetic Factors and Presumptive Enteroviral Etiology or Protection. Journal of Pathogens،Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1042771
Modern Language Association (MLA)
Precechtelova, Jana…[et al.]. Type I Diabetes Mellitus: Genetic Factors and Presumptive Enteroviral Etiology or Protection. Journal of Pathogens No. 2014 (2014), pp.1-21.
https://search.emarefa.net/detail/BIM-1042771
American Medical Association (AMA)
Precechtelova, Jana& Borsanyiova, Maria& Sarmirova, Sona& Bopegamage, Shubhada. Type I Diabetes Mellitus: Genetic Factors and Presumptive Enteroviral Etiology or Protection. Journal of Pathogens. 2014. Vol. 2014, no. 2014, pp.1-21.
https://search.emarefa.net/detail/BIM-1042771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042771