Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential

Joint Authors

Ansari, Moiz A.
Fatima, Zeeshan
Hameed, Saif

Source

Journal of Pathogens

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-12-09

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Diseases
Medicine

Abstract EN

We investigated the antifungal effects of sesamol (Ses), a natural phenolic compound, and exemplified that it could be mediated through disruption of calcineurin signaling pathway in C.

albicans, a human fungal pathogen.

The repertoire of antifungal activity not only was limited to C.

albicans and its six clinical isolates tested but also was against non-albicans species of Candida.

Interestingly, the antifungal effect of Ses affects neither the MDR efflux transporter activity nor passive diffusion of drug.

We found that C.

albicans treated with Ses copies the phenotype displayed by cells having defect in calcineurin signaling leading to sensitivity against alkaline pH, ionic, membrane, salinity, endoplasmic reticulum, and serum stresses but remained resistant to thermal stress.

Furthermore, the ergosterol levels were significantly decreased by 63% confirming membrane perturbations in response to Ses as also visualized through transmission electron micrographs.

Despite the fact that Ses treatment mimics the phenotype of compromised calcineurin signaling, it was independent of cell wall integrity pathway as revealed by spot assays and the scanning electron micrographs.

Taken together, the data procured from this study clearly ascertains that Ses is an effectual antifungal agent that could be competently employed in treating Candida infections.

American Psychological Association (APA)

Ansari, Moiz A.& Fatima, Zeeshan& Hameed, Saif. 2014. Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential. Journal of Pathogens،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1042776

Modern Language Association (MLA)

Ansari, Moiz A.…[et al.]. Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential. Journal of Pathogens No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1042776

American Medical Association (AMA)

Ansari, Moiz A.& Fatima, Zeeshan& Hameed, Saif. Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential. Journal of Pathogens. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1042776

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1042776