Locally Advanced and Unresectable Cutaneous Squamous Cell Carcinoma: Outcomes of Concurrent Cetuximab and Radiotherapy
Joint Authors
Samstein, Robert M.
Ho, Alan L.
Lee, Nancy Y.
Barker, Christopher A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Advanced age and immune dysfunction are risk factors for cutaneous squamous cell carcinoma (cSCC) and often render patients with locally-advanced disease medically inoperable or surgically unresectable, but potentially curable with radiotherapy.
Concurrent chemotherapy and radiotherapy may not be well tolerated in this population, but another systemic therapy may improve disease control.
Objective.
Determine the tolerance and efficacy of concurrent cetuximab and radiotherapy (CRT) for patients with locally advanced and unresectable cSCC.
Methods.
Retrospective analysis of 12 patients treated with CRT for locally advanced and unresectable cSCC.
Results.
Patients were elderly and 75% had moderate-to-severe comorbidities, while 42% had immune dysfunction.
Grades 3-4 adverse events were noted in 83% of patients; 67% required hospital admission for adverse events.
Complete and partial response was noted in 36% and 27% (response rate, 64%).
Stable and progressive disease was noted in 3 and 1 patients, respectively (disease control rate, 91%).
Median progression-free and overall survival were 6.4 and 8.0 months, respectively.
Limitations.
Retrospective small-cohort, single-institution analysis.
Conclusion.
Patients selected for CRT were elderly, with comorbidities and immune dysfunction, but treatment responses were observed.
Patients selected for this treatment approach have a poor prognosis with limited capacity for therapy; more effective treatment is needed.
American Psychological Association (APA)
Samstein, Robert M.& Ho, Alan L.& Lee, Nancy Y.& Barker, Christopher A.. 2014. Locally Advanced and Unresectable Cutaneous Squamous Cell Carcinoma: Outcomes of Concurrent Cetuximab and Radiotherapy. Journal of Skin Cancer،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043022
Modern Language Association (MLA)
Samstein, Robert M.…[et al.]. Locally Advanced and Unresectable Cutaneous Squamous Cell Carcinoma: Outcomes of Concurrent Cetuximab and Radiotherapy. Journal of Skin Cancer No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043022
American Medical Association (AMA)
Samstein, Robert M.& Ho, Alan L.& Lee, Nancy Y.& Barker, Christopher A.. Locally Advanced and Unresectable Cutaneous Squamous Cell Carcinoma: Outcomes of Concurrent Cetuximab and Radiotherapy. Journal of Skin Cancer. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043022