The Influence of the Coexpression of CD4 and CD8 in Cutaneous Lesions on Prognosis of Mycosis Fungoides: A Preliminary Study
Joint Authors
Errichetti, Enzo
di Meo, Nicola
Bonin, Serena
De Marchi, Sergio Umberto
Trevisan, Giusto
Stinco, Giuseppe
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Although techniques of immunophenotyping have been successful in characterizing the cells in the cutaneous infiltrates of mycosis fungoides little evidence suggests that variations in the phenotypic characterization correlate with prognosis.
Objectives.
In a preliminary prospective, single-centre, study we correlated the T-cell phenotype in cutaneous biopsies with the progression of the disease to determine whether the coexpression of CD4 and CD8 has an impact on prognosis.
Methods.
Skin biopsy specimens from 30 newly diagnosed patients were stained with immunoperoxidase techniques to determine their phenotypic characteristics.
After a median followup of 42 months patients were divided into two groups with stable and progressive disease.
Results.
Eighteen patients had the conventional CD4+CD8− T-cell phenotype.
Ten patients showed the coexpression of CD4 and CD8 and had a slightly lower rate of progressive disease.
Conclusions.
The coexpression of CD4 and CD8 in cutaneous lesions is not rare and is associated with a slightly lower rate of progressive disease.
Since double positive CD4/CD8 phenotype is rarely reported in mycosis fungoides the presence on conventional immunophenotyping of both CD may be due to a “mixture” of neoplastic cells and inflammatory CD8+ tumor infiltrating lymphocytes.
Immunohistochemical study combined with confocal microscopy could clarify this issue.
American Psychological Association (APA)
De Marchi, Sergio Umberto& Stinco, Giuseppe& Errichetti, Enzo& Bonin, Serena& di Meo, Nicola& Trevisan, Giusto. 2014. The Influence of the Coexpression of CD4 and CD8 in Cutaneous Lesions on Prognosis of Mycosis Fungoides: A Preliminary Study. Journal of Skin Cancer،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1043031
Modern Language Association (MLA)
De Marchi, Sergio Umberto…[et al.]. The Influence of the Coexpression of CD4 and CD8 in Cutaneous Lesions on Prognosis of Mycosis Fungoides: A Preliminary Study. Journal of Skin Cancer No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1043031
American Medical Association (AMA)
De Marchi, Sergio Umberto& Stinco, Giuseppe& Errichetti, Enzo& Bonin, Serena& di Meo, Nicola& Trevisan, Giusto. The Influence of the Coexpression of CD4 and CD8 in Cutaneous Lesions on Prognosis of Mycosis Fungoides: A Preliminary Study. Journal of Skin Cancer. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1043031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043031