Prognostic Value of Melanoma Inhibitory Activity Protein in Localized Cutaneous Malignant Melanoma

Abstract EN

Background.

Cutaneous malignant melanoma (CMM) is a heterogeneous disease, acknowledged for its lack of predictability regarding clinical evolution.

In order to appreciate a patient’s individual prognosis, an attempt is made to find new tumor markers that parallel the disease progression.

Objective.

To identify if melanoma inhibitory activity (MIA) protein could represent a tool for selecting high risk early stages melanoma patients.

Method.

Between 2008 and 2013, 155 patients with CMM were treated in our clinic.

84 of them were classified into stages I and II, according to TNM 2009.

MIA serum concentration was measured in all patients and 50 healthy donors.

A cut-off value of 9.4 ng/ml was established using the ROC curve.

Results.

All patients were followed up by periodic investigations every 6 months.

We have noticed that 66% of patients with MIA serum values at diagnosis greater than 9.4 ng/mL have relapsed, while only 5% of patients with MIA serum concentration below the estimated threshold, recurred during the follow-up period (P=0.000).

The death risk was 12 times higher in pathological MIA group of patients (P=0.0001).

Conclusions.

Our data suggest that MIA is an independent prognostic factor for patients with localized CMM.