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Interaction of Hyperoside with Human Serum Albumin and Effect of Glucose on the Binding
Joint Authors
Yang, Jie
Qu, Lingling
Yang, Wenyue
Huang, Yun
Jiao, Ning
Zhan, Wenhong
Zhao, Ding
Cui, Lijian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The interaction of hyperoside (Hyp) with human serum albumin (HSA) and effect of glucose on the binding were studied in simulating physiological condition (pH 7.40).
The results suggested that Hyp quenched the endogenous fluorescence of HSA via a static quenching process with the distance of 1.95 nm between Hyp and HSA.
Hydrophobic forces played a major role in stabilizing the Hyp-HSA complex.
Through synchronous fluorescence monitoring of conformation of HSA, we found that the binding to Hyp can change the microenvironment around tryptophan (Trp) residues.
Increasing in glucose concentration over a range from 0 to 9 mM decreased the binding ability of HSA to Hyp, implying that increasing in glucose concentration would increase the concentration of free Hyp.
American Psychological Association (APA)
Yang, Jie& Qu, Lingling& Yang, Wenyue& Huang, Yun& Jiao, Ning& Zhan, Wenhong…[et al.]. 2014. Interaction of Hyperoside with Human Serum Albumin and Effect of Glucose on the Binding. Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043090
Modern Language Association (MLA)
Yang, Jie…[et al.]. Interaction of Hyperoside with Human Serum Albumin and Effect of Glucose on the Binding. Journal of Spectroscopy No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043090
American Medical Association (AMA)
Yang, Jie& Qu, Lingling& Yang, Wenyue& Huang, Yun& Jiao, Ning& Zhan, Wenhong…[et al.]. Interaction of Hyperoside with Human Serum Albumin and Effect of Glucose on the Binding. Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043090