Radical Reactions in the Gas Phase: Recent Development and Application in Biomolecules
Joint Authors
Gao, Yang
Bu, Jiexun
Peng, Zhou
Yang, Biwei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This review summarizes recent literature describing the use of gas phase radical reactions for structural characterization of complex biomolecules other than peptides.
Specifically, chemical derivatization, in-source chemical reaction, and gas phase ion/ion reactions have been demonstrated as effective ways to generate radical precursor ions that yield structural informative fragments complementary to those from conventional collision-induced dissociation (CID).
Radical driven dissociation has been applied to a variety of biomolecules including peptides, nucleic acids, carbohydrates, and phospholipids.
The majority of the molecules discussed in this review see limited fragmentation from conventional CID, and the gas phase radical reactions open up completely new dissociation channels for these molecules and therefore yield high fidelity confirmation of the structures of the target molecules.
Due to the extensively studied peptide fragmentation, this review focuses only on nonpeptide biomolecules such as nucleic acids, carbohydrates, and phospholipids.
American Psychological Association (APA)
Gao, Yang& Bu, Jiexun& Peng, Zhou& Yang, Biwei. 2014. Radical Reactions in the Gas Phase: Recent Development and Application in Biomolecules. Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043107
Modern Language Association (MLA)
Gao, Yang…[et al.]. Radical Reactions in the Gas Phase: Recent Development and Application in Biomolecules. Journal of Spectroscopy No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043107
American Medical Association (AMA)
Gao, Yang& Bu, Jiexun& Peng, Zhou& Yang, Biwei. Radical Reactions in the Gas Phase: Recent Development and Application in Biomolecules. Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043107