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Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering
Joint Authors
Skołuba, Dominika
Sobolewski, Dariusz
Prahl, Adam
Proniewicz, Edyta
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bradykinin (BK), an endogenous peptide hormone, which is involved in a number of physiological and pathophysiological processes, and the potent B2 bradykinin receptor antagonists, [D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, Aaa[D-Arg0,Hyp3,Thi5,8,L-Pip7]BK, [D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, and Aaa[D-Arg0,Hyp3,Thi5,D-Phe7,L-Pip8]BK, were deposited onto colloidal Au particles of 20 nm size.
Interaction of these molecules with colloidal Au surface was explored by surface-enhanced Raman scattering (SERS).
Briefly, it was shown that BK adsorbs on the Au surface mainly through the Phe5/Phe8 residues.
In case of the BK specifically modified analogues mainly the Pip and Thi rings are involved in the interaction process; however, Pip and Thi adopt slightly different orientation with respect to Au for each of the analogues.
In addition, the lack of the Aaa vibrations, together with the enhancement of the Thi, Pip, or Phe modes, emphasizes the importance of the C-terminus in the interaction with the Au surface.
American Psychological Association (APA)
Skołuba, Dominika& Sobolewski, Dariusz& Prahl, Adam& Proniewicz, Edyta. 2014. Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering. Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043119
Modern Language Association (MLA)
Skołuba, Dominika…[et al.]. Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering. Journal of Spectroscopy No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043119
American Medical Association (AMA)
Skołuba, Dominika& Sobolewski, Dariusz& Prahl, Adam& Proniewicz, Edyta. Interaction of Bradykinin and B2 Bradykinin Receptor Antagonists with Colloidal Au Surface Explored by Surface-Enhanced Raman Scattering. Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043119