![](/images/graphics-bg.png)
Physicochemical Analysis and Molecular Modeling of the Fosinopril β-Cyclodextrin Inclusion Complex
Joint Authors
Udrescu, Lucreția
Sbârcea, Laura
Fuliaș, Adriana
Ledeți, Ionuț
Vlase, Gabriela
Barvinschi, Paul
Kurunczi, Ludovic
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-06
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This research investigates the interaction between fosinopril sodium (FOS) and beta-cyclodextrin (β-CD) in aqueous solution and in solid state, in order to prove the formation of an inclusion complex between the two components.
The stoichiometry of the inclusion complex was found as 1 : 1 by employing continuous variation method in UV.
The formation constant was calculated as 278.93 M−1 using Benesi-Hildebrand equation.
The kneaded product (KP) and the physical mixture (PM) were further experimentally examined, using FTIR, powder X-ray diffractometry, and thermal analysis.
The results confirm that the physicochemical properties of the FOS/β-CD KP are different from FOS and that the kneading method leads to formation of solid state inclusion complex between FOS and β-CD.
Structural studies of the FOS/β-CD were carried out using molecular modeling techniques, in order to explain the complexation mechanism and the host-guest geometry.
American Psychological Association (APA)
Udrescu, Lucreția& Sbârcea, Laura& Fuliaș, Adriana& Ledeți, Ionuț& Vlase, Gabriela& Barvinschi, Paul…[et al.]. 2014. Physicochemical Analysis and Molecular Modeling of the Fosinopril β-Cyclodextrin Inclusion Complex. Journal of Spectroscopy،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043137
Modern Language Association (MLA)
Udrescu, Lucreția…[et al.]. Physicochemical Analysis and Molecular Modeling of the Fosinopril β-Cyclodextrin Inclusion Complex. Journal of Spectroscopy No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043137
American Medical Association (AMA)
Udrescu, Lucreția& Sbârcea, Laura& Fuliaș, Adriana& Ledeți, Ionuț& Vlase, Gabriela& Barvinschi, Paul…[et al.]. Physicochemical Analysis and Molecular Modeling of the Fosinopril β-Cyclodextrin Inclusion Complex. Journal of Spectroscopy. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043137