Use of Novel Polyurethane Microspheres in a Curcumin Delivery System

Abstract EN

Despite having a wide range of beneficial pharmacological effects, curcumin is characterized by poor water solubility and absorption.

In this study, novel polyurethane microspheres containing curcumin (Cur-PUMs) were prepared using carboxymethyl cellulose sodium to improve the bioavailability and prolong the retention time of curcumin.

The prepared Cur-PUMs were characterized by Fourier transform infrared spectroscopy, scanning electron microscope, and ultraviolet spectrophotometer.

The sustained-release effects of Cur-PUMs were demonstrated using stability tests in vitro and in vivo pharmacokinetic studies following oral administration.

We found that the stability of Cur-PUMs was strongly affected by pH variation.

Further, compared with free curcumin, Cur-PUMs showed significantly improved maximum concentration and half-life.