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Toxicological Study of Ocimum sanctum Linn Leaves: Hematological, Biochemical, and Histopathological Studies
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study was aimed to study the acute and subacute toxicity studies with orally administered 50% ethanolic leaves extract of Ocimum sanctum Linn (OSE).
In acute toxicity tests, four groups of mice ( n = 6 /group/sex ) were orally treated with doses of 200, 600, and 2000 mg/kg, and general behavior, adverse effects, and mortality were recorded for up to 14 days.
In subacute toxicity study, rats received OSE by gavage at the doses of 200, 400, and 800 mg/kg/day ( n = 6 /group/sex ) for 28 days, and biochemical, hematological, and histopathological changes in tissues (liver, kidney, spleen, heart, and testis/ovary) were determined.
OSE did not produce any hazardous symptoms or death and CNS and ANS toxicities in the acute toxicity test.
Subacute treatment with OSE did not show any change in body weight, food and water consumption, and hematological and biochemical profiles.
In addition, no change was observed both in macroscopic and microscopic aspects of vital organs in rats.
Our result showed that Ocimum sanctum extract could be safe for human use.
American Psychological Association (APA)
Gautam, M. K.& Goel, R. K.. 2014. Toxicological Study of Ocimum sanctum Linn Leaves: Hematological, Biochemical, and Histopathological Studies. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043167
Modern Language Association (MLA)
Gautam, M. K.& Goel, R. K.. Toxicological Study of Ocimum sanctum Linn Leaves: Hematological, Biochemical, and Histopathological Studies. Journal of Toxicology No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043167
American Medical Association (AMA)
Gautam, M. K.& Goel, R. K.. Toxicological Study of Ocimum sanctum Linn Leaves: Hematological, Biochemical, and Histopathological Studies. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043167