Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism
Joint Authors
Yadav, Anita
Kumar, Neeraj
Gulati, Sachin
Kanupriya, Sachin
Gupta, Ranjan
Aggarwal, Neeraj Kumar
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In recent years, the use of organophosphorus pesticides has been extensively increased and these compounds signify a major class of agricultural pesticides today.
We studied antigenotoxic potential of curcumin and carvacrol against the parathion induced DNA damage in cultured peripheral blood lymphocytes using sister chromatid exchanges as a biomarker of genotoxicity.
Heparinised fresh blood from healthy individuals was treated with 2.5 μg/mL concentration of parathion in presence of curcumin and carvacrol in order to observe the antigenotoxic potential of both curcumin and carvacrol.
Significant reduction ( P < 0.05 ) was observed in the frequencies of SCEs in presence of 10 μg/mL and 15 μg/mL concentrations of curcumin as compared to parathion exposed sample.
Similarly carvacrol had significant ( P < 0.05 ) antigenotoxic effect at the concentrations of 2.5 μg/mL and 5.0 μg/mL against the parathion.
We also studied the effect of GSTT1 and GSTM1 on genotoxicity of parathion and antigenotoxic potential of curcumin and carvacrol.
We did not observe any significant effect ( P > 0.05 ) of GSTT1 and GSTM1 polymorphism on genotoxicity of parathion and antigenotoxic potential of curcumin and carvacrol.
American Psychological Association (APA)
Kumar, Neeraj& Yadav, Anita& Gulati, Sachin& Kanupriya, Sachin& Aggarwal, Neeraj Kumar& Gupta, Ranjan. 2014. Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043189
Modern Language Association (MLA)
Kumar, Neeraj…[et al.]. Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism. Journal of Toxicology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043189
American Medical Association (AMA)
Kumar, Neeraj& Yadav, Anita& Gulati, Sachin& Kanupriya, Sachin& Aggarwal, Neeraj Kumar& Gupta, Ranjan. Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043189