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Anion Gap Toxicity in Alloxan Induced Type 2 Diabetic Rats Treated with Antidiabetic Noncytotoxic Bioactive Compounds of Ethanolic Extract of Moringa oleifera
Joint Authors
Omabe, Maxwell
Nwudele, Chibueze
Omabe, Kenneth Nwobini
Okorocha, Albert Egwu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Moringa oleifera (MO) is used for a number of therapeutic purposes.
This raises the question of safety and possible toxicity.
The objective of the study was to ascertain the safety and possible metabolic toxicity in comparison with metformin, a known drug associated with acidosis.
Animals confirmed with diabetes were grouped into 2 groups.
The control group only received oral dose of PBS while the test group was treated with ethanolic extract of MO orally twice daily for 5-6 days.
Data showed that the extract significantly lowered glucose level to normal values and did not cause any significant cytotoxicity compared to the control group (P=0.0698); there was no gain in weight between the MO treated and the control groups (P>0.8115).
However, data showed that treatment with an ethanolic extract of MO caused a decrease in bicarbonate (P<0.0001), and more than twofold increase in anion gap (P<0.0001); metformin treatment also decreased bicarbonate (P<0.0001) and resulted in a threefold increase in anion gap (P<0.0001).
Conclusively, these data show that while MO appears to have antidiabetic and noncytotoxic properties, it is associated with statistically significant anion gap acidosis in alloxan induced type 2 diabetic rats.
American Psychological Association (APA)
Omabe, Maxwell& Nwudele, Chibueze& Omabe, Kenneth Nwobini& Okorocha, Albert Egwu. 2014. Anion Gap Toxicity in Alloxan Induced Type 2 Diabetic Rats Treated with Antidiabetic Noncytotoxic Bioactive Compounds of Ethanolic Extract of Moringa oleifera. Journal of Toxicology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043191
Modern Language Association (MLA)
Omabe, Maxwell…[et al.]. Anion Gap Toxicity in Alloxan Induced Type 2 Diabetic Rats Treated with Antidiabetic Noncytotoxic Bioactive Compounds of Ethanolic Extract of Moringa oleifera. Journal of Toxicology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043191
American Medical Association (AMA)
Omabe, Maxwell& Nwudele, Chibueze& Omabe, Kenneth Nwobini& Okorocha, Albert Egwu. Anion Gap Toxicity in Alloxan Induced Type 2 Diabetic Rats Treated with Antidiabetic Noncytotoxic Bioactive Compounds of Ethanolic Extract of Moringa oleifera. Journal of Toxicology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043191